
Preheat oven to 400 degrees.
Place shrimp in a medium bowl with olive oil, garlic, salt, red pepper flakes (if using) and black pepper. Toss gently to coat and set aside.
Spray a large sheet pan with olive oil spray. Place broccolini and tomatoes on the sheet pan and toss with olive oil, salt, pepper and oregano. Spread out in an even layer. Roast for 15 minutes, tossing halfway through.
Remove sheet pan from oven and add shrimp, placing them evenly around the veggies. Roast for 8 minutes.
Top everything with lemon juice and serve.